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Single-Molecular Poly(propylene oxide) (PPO) Nucleus-Guided Assembly for Hydrophobicity-Dependent Molecular Transport in the Nanopore
Langmuir ( IF 3.7 ) Pub Date : 2023-03-16 , DOI: 10.1021/acs.langmuir.3c00447 Jianhan Ye 1, 2 , Juanjuan Zheng 3 , Xin Lu 3 , Fen Wu 3 , Nannan Liu 3 , Yuanchen Dong 2 , Qian Shi 3 , Lijin Xu 1 , Dongsheng Liu 4
Langmuir ( IF 3.7 ) Pub Date : 2023-03-16 , DOI: 10.1021/acs.langmuir.3c00447 Jianhan Ye 1, 2 , Juanjuan Zheng 3 , Xin Lu 3 , Fen Wu 3 , Nannan Liu 3 , Yuanchen Dong 2 , Qian Shi 3 , Lijin Xu 1 , Dongsheng Liu 4
Affiliation
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By combining DNA nanotechnology and solid-phase nanopore technology, the aggregation behavior of polymer guided by a single-molecular poly(propylene) (PPO) nucleus in a 3D DNA network has been studied. At low temperature, the PPO chain is evenly dispersed in the rigid 3D DNA network; at higher temperature, the PPO chain self-collapses to a single-molecular nucleus; and upon addition of amphiphilic block copolymers below the critical micelle concentration (CMC), the chains tend to aggregate on the isolated hydrophobic nucleus through intermolecular hydrophobic interactions. The process has been characterized by a rheological test and an electrochemical test. This study not only provides a preliminary understanding of the nucleation and growth process of block copolymers but also offers a theoretical basis for the study of protein self-folding and aggregation in the future. On this basis, utilizing this nucleation and growth event, a novel smart nanopore has been developed for hydrophobicity-dependent molecular transport.
中文翻译：
用于纳米孔中疏水性依赖性分子传输的单分子聚（环氧丙烷）（PPO）核引导组装
通过结合 DNA 纳米技术和固相纳米孔技术，研究了 3D DNA 网络中由单分子聚（丙烯）（PPO）核引导的聚合物的聚集行为。在低温下，PPO链均匀分散在刚性的3D DNA网络中；在更高的温度下，PPO 链会自行坍缩成单分子核；当添加低于临界胶束浓度 (CMC) 的两亲性嵌段共聚物时，链倾向于通过分子间疏水相互作用聚集在孤立的疏水核上。该过程已通过流变测试和电化学测试表征。该研究不仅初步了解了嵌段共聚物的成核和生长过程，也为今后蛋白质自折叠和聚集的研究提供了理论基础。在此基础上，利用这种成核和生长事件，开发了一种新型智能纳米孔，用于疏水性依赖性分子传输。
更新日期：2023-03-16
中文翻译：
用于纳米孔中疏水性依赖性分子传输的单分子聚（环氧丙烷）（PPO）核引导组装
通过结合 DNA 纳米技术和固相纳米孔技术，研究了 3D DNA 网络中由单分子聚（丙烯）（PPO）核引导的聚合物的聚集行为。在低温下，PPO链均匀分散在刚性的3D DNA网络中；在更高的温度下，PPO 链会自行坍缩成单分子核；当添加低于临界胶束浓度 (CMC) 的两亲性嵌段共聚物时，链倾向于通过分子间疏水相互作用聚集在孤立的疏水核上。该过程已通过流变测试和电化学测试表征。该研究不仅初步了解了嵌段共聚物的成核和生长过程，也为今后蛋白质自折叠和聚集的研究提供了理论基础。在此基础上，利用这种成核和生长事件，开发了一种新型智能纳米孔，用于疏水性依赖性分子传输。
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