Transition metal-catalyzed alkynylation reactions via alkynyl carbon–carbon bond cleavage,Organic Chemistry Frontiers

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Transition metal-catalyzed alkynylation reactions via alkynyl carbon–carbon bond cleavage
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2023-03-16 , DOI: 10.1039/d3qo00225j
Hairui Yuan ₁ , Qi Zhou ₁ , Jianbo Wang _{1,

2}

Affiliation

It is of great significance to realize the alkynylation of the reaction since alkynes are widely present in natural products and biologically active molecules. And at the same time alkynes have very rich transformations in synthetic organic chemistry. It is also attractive to functionalize molecules by cleaving inert carbon–carbon bonds albeit with great challenge due to their inherent stability. Recently, significant progress has been made in the cleavage of alkynyl carbon–carbon single bonds for enabling the alkynylation of organic molecules. This review focuses on the recent advances in transition-metal-catalyzed cleavage and transformation of alkynyl carbon–carbon bonds with alkynoic acids, propargylic alcohols, alkynyl esters, and alkynyl ketones.

中文翻译：

通过炔基碳-碳键断裂的过渡金属催化炔基化反应

炔烃广泛存在于天然产物和生物活性分子中，实现该反应的炔基化具有重要意义。同时炔烃在合成有机化学中有非常丰富的转化。通过切割惰性碳-碳键来使分子功能化也很有吸引力，尽管由于其固有的稳定性而面临巨大挑战。最近，在炔基碳-碳单键的裂解以实现有机分子的炔基化方面取得了重大进展。本综述重点介绍了过渡金属催化的炔基碳-碳键与炔酸、炔丙醇、炔基酯和炔基酮的裂解和转化的最新进展。

更新日期：2023-03-20

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