ObjectiveThis study aimed to investigate the correlation between serum laminin (LN) levels and clinical stages of heart failure in patients with chronic heart failure.MethodsA total of 277 patients with chronic heart failure were selected from September 2019 to June 2020 in the Department of Cardiology, Second Affiliated Hospital of Nantong University. Based on stages of heart failure, the patients were divided into four groups: stage A, stage B, stage C, and stage D, with 55, 54, 77, and 91 cases, respectively. At the same time, 70 healthy people in this period were selected as the control group. Baseline data were recorded and serum Laminin (LN) levels were measured. The research compared, the differences in baseline data among the four groups of HF and normal controls, and analyzed the correlation between N-terminal pro-brain natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF). The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of LN in the C-D stage of heart failure. Logistic multivariate ordered analysis was applied to screen the independent related factors of clinical stages of heart failure.ResultsSerum LN levels in patients with chronic heart failure were significantly higher than those in healthy people, which were 33.2 (21.38, 101.9) ng/ml and 20.45 (15.53, 23.04) ng/ml, respectively. With the progression of clinical stages of HF, serum LN and NT-proBNP levels increased, while LVEF gradually decreased (P < 0.05). Correlation analysis showed that LN was positively correlated with NT-proBNP (r = 0.744, P = 0.000) and negatively correlated with LVEF (r = −0.568, P = 0.000). The area under the ROC curve of LN for predicting C and D stages of heart failure was 0.913, 95% confidence interval was 0.882–0.945, P = 0.000, specificity 94.97%, and sensitivity 77.38%. Multivariate Logistic analysis showed that LN, Total bilirubin, NT-proBNP and HA were all independent correlates of heart failure staging.ConclusionSerum LN levels in patients with chronic heart failure are significantly increased and are independently correlated with the clinical stages of heart failure. It could potentially be an early warning index of the progression and severity of heart failure.

中文翻译：

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慢性心力衰竭患者血清层粘连蛋白水平与心力衰竭严重程度的相关性

目的本研究旨在探讨慢性心力衰竭患者血清层粘连蛋白（LN）水平与心力衰竭临床分期的相关性。方法选取2019年9月至2020年6月心内科277例慢性心力衰竭患者，南通大学第二附属医院; 根据心衰分期将患者分为A期、B期、C期、D期4组，分别为55例、54例、77例和91例。同时选取本期健康人70例作为对照组。记录基线数据并测量血清层粘连蛋白 (LN) 水平。研究比较，四组HF与正常对照组基线数据的差异，并分析了 N 末端脑利钠肽原 (NT-proBNP) 与左心室射血分数 (LVEF) 的相关性。采用受试者工作特征（ROC）曲线评价LN对CD期心力衰竭的预测价值。应用Logistic多变量有序分析筛选影响心力衰竭临床分期的独立相关因素。结果慢性心力衰竭患者血清LN水平显着高于健康人，分别为33.2（21.38，101.9）ng/ml和20.45 (15.53, 23.04) 纳克/毫升，分别。随着 HF 临床分期的进展，血清 LN 和 NT-proBNP 水平升高，而 LVEF 逐渐降低（采用受试者工作特征（ROC）曲线评价LN对CD期心力衰竭的预测价值。应用Logistic多变量有序分析筛选影响心力衰竭临床分期的独立相关因素。结果慢性心力衰竭患者血清LN水平显着高于健康人，分别为33.2（21.38，101.9）ng/ml和20.45 (15.53, 23.04) 纳克/毫升，分别。随着 HF 临床分期的进展，血清 LN 和 NT-proBNP 水平升高，而 LVEF 逐渐降低（采用受试者工作特征（ROC）曲线评价LN对CD期心力衰竭的预测价值。应用Logistic多变量有序分析筛选影响心力衰竭临床分期的独立相关因素。结果慢性心力衰竭患者血清LN水平显着高于健康人，分别为33.2（21.38，101.9）ng/ml和20.45 (15.53, 23.04) 纳克/毫升，分别。随着 HF 临床分期的进展，血清 LN 和 NT-proBNP 水平升高，而 LVEF 逐渐降低（结果慢性心力衰竭患者血清LN水平显着高于健康人，分别为33.2（21.38，101.9）ng/ml和20.45（15.53，23.04）ng/ml。随着 HF 临床分期的进展，血清 LN 和 NT-proBNP 水平升高，而 LVEF 逐渐降低（结果慢性心力衰竭患者血清LN水平显着高于健康人，分别为33.2（21.38，101.9）ng/ml和20.45（15.53，23.04）ng/ml。随着 HF 临床分期的进展，血清 LN 和 NT-proBNP 水平升高，而 LVEF 逐渐降低（P< 0.05）。相关性分析显示，LN与NT-proBNP呈正相关（r= 0.744,P= 0.000) 并且与 LVEF 呈负相关 (r= −0.568,P= 0.000）。LN预测心力衰竭C、D期的ROC曲线下面积为0.913，95%置信区间为0.882~0.945，P= 0.000，特异性为 94.97%，敏感性为 77.38%。多因素Logistic分析显示LN、总胆红素、NT-proBNP和HA均为心力衰竭分期的独立相关因素。它可能是心力衰竭进展和严重程度的早期预警指标。