Plasmonic nanostructures have a desirable surface-enhanced Raman scattering (SERS) response related to particle spacing. However, precisely controlling the distance of plasmonic nanostructures is still a challenge. DNA has the merit of specific recognition, and flexible modification of functional groups, which can be used to flexibly adjust the gaps between plasmonic nanostructures for improving the stability of SERS. In this paper, DNA-guided gold nanoparticles formed one-dimensional ordered structures and they were self-assembled at the water–oil interface by a bottom-up approach. Notably, an output switching strategy successfully transfers a small amount of target into a large amount of reporter DNA; thereby, Raman probes are captured on the sensing interface and achieve the SERS assay of microRNA 155 (miRNA-155). This study is an exciting strategy for obtaining ordered plasmonic structures and providing surveillance, which is important for the clinical diagnosis of early-stage cancer.

中文翻译：

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用于 SERS 生物测定的 DNA 引导的一维等离子体纳米结构

等离子体纳米结构具有与粒子间距相关的理想表面增强拉曼散射 (SERS) 响应。然而，精确控制等离子体纳米结构的距离仍然是一个挑战。DNA具有特异性识别、官能团修饰灵活等优点，可用于灵活调整等离子体纳米结构之间的空隙，提高SERS的稳定性。在本文中，DNA 引导的金纳米粒子形成一维有序结构，并通过自下而上的方法在水-油界面自组装。值得注意的是，输出切换策略成功地将少量目标转移到大量报告 DNA 中；从而将拉曼探针捕获在传感界面上，实现微小RNA 155（miRNA-155）的SERS检测。