Two new flavonoids, 8,2′-diprenyl-3,5,7,5′-tetrahydroxyflavone (1) and 8-(1-methoxy-2,3-dihydroxy-3-methylbutyl)naringenin (2), along with twelve known compounds (3–14), were isolated from the leaves of Macaranga pustulata. The structures of the new compounds 1 and 2 were established by detailed spectroscopic data analysis and ECD computational methods. The inhibitory effects of compounds 1–6 against NLRP3 inflammasome activation as well as the cytotoxic activities of compounds 1–4 against MCF-7 and HCT-116 cancer cell lines were investigated. Compound 3 showed weak cytotoxicity against HCT-116 (IC₅₀ = 55.747 ± 3.212 μM).

两种新的类黄酮，8,2'-diprenyl-3,5,7,5'-tetrahydroxyflavone ( 1 ) 和 8-(1-methoxy-2,3-dihydroxy-3-methylbutyl)naringenin ( 2 )，以及十二种已知化合物 ( 3–14 ) 是从Macaranga pustulata的叶子中分离出来的。通过详细的光谱数据分析和 ECD 计算方法确定了新化合物1和2的结构。研究了化合物1-6对 NLRP3 炎性体激活的抑制作用以及化合物1-4对 MCF-7 和 HCT-116 癌细胞系的细胞毒活性。化合物3显示出对 HCT-116 的弱细胞毒性 (IC₅₀ = 55.747 ± 3.212 μM）。