Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers.,JAMA Neurology

当前位置： X-MOL 学术 › JAMA Neurol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers.
JAMA Neurology ( IF 20.4 ) Pub Date : 2023-02-06 , DOI: 10.1001/jamaneurol.2022.5272
Niklas Mattsson-Carlgren _{1,

2,

3} , Gemma Salvadó ₁ , Nicholas J Ashton _{4,

5,

6,

7} , Pontus Tideman _{1,

8} , Erik Stomrud _{1,

8} , Henrik Zetterberg _{4,

9,

10,

11,

12} , Rik Ossenkoppele _{1,

13,

14} , Tobey J Betthauser _{15,

16} , Karly Alex Cody _{15,

16} , Erin M Jonaitis _{15,

16} , Rebecca Langhough _{15,

16} , Sebastian Palmqvist _{1,

8} , Kaj Blennow _{4,

9} , Shorena Janelidze ₁ , Sterling C Johnson _{15,

16} , Oskar Hansson _{1,

8}

Affiliation

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.
Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.
Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London, United Kingdom.
NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, United Kingdom.
Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
Memory Clinic, Skåne University Hospital, Lund University, Lund, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom.
UK Dementia Research Institute at University College London, London, United Kingdom.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, Hong Kong SAR, China.
Alzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Amsterdam Neuroscience, Neurodegeneration Program, Amsterdam University Medical Centers, the Netherlands.
Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison.
Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison.

Alzheimer disease (AD) pathology starts with a prolonged phase of β-amyloid (Aβ) accumulation without symptoms. The duration of this phase differs greatly among individuals. While this disease phase has high relevance for clinical trial designs, it is currently unclear how to best predict the onset of clinical progression.

中文翻译：