Blood contact materials require strong anti-fouling capabilities to avoid thrombus formation. Recently, TiO2-based photocatalytic antithrombotic treatment has gained focus. Nevertheless, this method is restricted to titanium materials with photocatalytic abilities. This study offers an alternative solution that can be applied to a broader range of materials: piranha solution treatment. Our findings revealed that the free radicals generated by the treatment effectively altered the surface physicochemical properties of various inorganic materials, enhancing their surface hydrophilicity and oxidizing organic contaminants, thus improving their antithrombotic properties. Additionally, the treatment resulted in contrasting effects on the cellular affinity of SS and TiO2. While it significantly reduced the adhesion and proliferation of SMCs on SS surfaces, it significantly enhanced these on TiO2 surfaces. These observations suggested that the impact of the piranha solution treatment on the cellular affinity of biomaterials was closely tied to the intrinsic properties of the materials. Thus, materials suitable for piranha solution treatment could be selected based on the functional requirements of implantable medical devices. In conclusion, the broad applicability of piranha solution surface modification technology in both blood-contact and bone implant materials highlights its promising prospects.

中文翻译：

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食人鱼溶液处理：一种提高血液接触材料抗血栓形成能力和调节平滑肌细胞生长的简便方法

血液接触材料需要很强的抗污能力，以避免血栓形成。最近，二氧化钛2个基于光催化的抗血栓治疗受到关注。然而，这种方法仅限于具有光催化能力的钛材料。本研究提供了一种可应用于更广泛材料的替代解决方案：食人鱼溶液处理。我们的研究结果表明，处理产生的自由基有效地改变了各种无机材料的表面物理化学性质，增强了它们的表面亲水性并氧化了有机污染物，从而改善了它们的抗血栓形成特性。此外，该处理对 SS 和 TiO2 的细胞亲和力产生了对比影响2个. 虽然它显着降低了 SMC 在 SS 表面上的粘附和增殖，但它显着增强了它们在 TiO2 上的粘附和增殖2个表面。这些观察结果表明，食人鱼溶液处理对生物材料细胞亲和力的影响与材料的固有特性密切相关。因此，可以根据植入式医疗器械的功能要求选择适合食人鱼溶液处理的材料。总之，食人鱼溶液表面改性技术在血液接触材料和骨植入材料中的广泛适用性凸显了其广阔的前景。