Drug use before or during sex is a high-risk sexual behavior associated with adverse health risks and outcomes, such as increasing the likelihood of overdoses and of acquiring sexually-transmitted diseases. This systematic review and meta-analysis of three scientific databases examined the prevalence of the use of intoxicating substances, those tending to excite or stupefy the user on a psychoactive level, before or during sex, among young adults (18–29 years old). A total of 55 unique empirical studies met the inclusion criteria (48,145 individuals; 39% males), were assessed for risk of bias using the tools of Hoy et al. (2012), and were analyzed via a generalized linear mixed-effects model. The results produced a global mean prevalence of this sexual risk behavior of 36.98% (95% CI: 28.28%, 46.63%). Nonetheless, significant differences were identified between different intoxicating substances, with the use of alcohol (35.10%; 95% CI: 27.68%, 43.31%), marijuana (27.80%; 95% CI: 18.24%, 39.92%), and ecstasy (20.90%; 95% CI: 14.34%, 29.45%) significantly more prevalent than that of cocaine (4.32%; 95% CI: 3.64%, 5.11%), heroin (.67%; 95% CI: .09%, 4.65%), methamphetamine (7.10%; 95% CI: 4.57%, 10.88%), and GHB (6.55%; 95% CI: 4.21%, 10.05%). Moderator analyses showed that the prevalence of alcohol use before or during sex differed according to geographical sample origin, and increased as the proportion of ethnic whites in samples increased. The remaining demographic (e.g., gender, age, reference population), sexual (e.g., sexual orientation, sexual activity), health (e.g., drug consumption, STI/STD status), methodological (e.g., sampling technique), and measurement (e.g., timeframe) variables that were examined did not moderate prevalence estimates. Implications for sexual development interventions were discussed.

性行为前或性行为过程中吸毒是一种高风险性行为，会带来不良健康风险和结果，例如增加用药过量和感染性传播疾病的可能性。这项对三个科学数据库的系统回顾和荟萃分析调查了年轻人（18-29 岁）在性行为前或性行为过程中使用致醉物质的流行情况，这些物质往往会在精神活性水平上使使用者兴奋或昏迷。共有 55 项独特的实证研究符合纳入标准（48,145 人；39% 男性），使用 Hoy 等人的工具评估了偏倚风险。（2012），并通过广义线性混合效应模型进行分析。结果显示，这种危险性行为的全球平均患病率为 36.98%（95% CI：28.28%、46.63%）。尽管如此，不同的致醉物质之间存在显着差异，其中使用酒精（35.10%；95% CI：27.68%、43.31%）、大麻（27.80%；95% CI：18.24%、39.92%）和摇头丸（ 20.90%; 95% CI: 14.34%, 29.45%) 明显高于可卡因 (4.32%; 95% CI: 3.64%, 5.11%)、海洛因 (.67%; 95% CI: 0.09%, 4.65) %）、甲基苯丙胺（7.10%；95% CI：4.57%、10.88%）和 GHB（6.55%；95% CI：4.21%、10.05%）。调节分析表明，性行为前或性行为过程中饮酒的流行率因样本地理来源的不同而有所不同，并且随着样本中白人比例的增加而增加。其余的人口统计（例如，性别、年龄、参考人群）、性（例如，性取向、性活动）、健康（例如，吸毒、STI/​​STD状况）、方法（例如，抽样技术）和测量（例如， 、时间范围）所检查的变量并没有调节患病率估计。讨论了性发育干预的影响。