Distinct subcellular localizations of mRNAs have been described across a wide variety of cell types. While common themes emerge for neuronal cells, functional roles of mRNA localization in space and time are much less understood in nonneuronal cells. Emerging areas of interest are cell models with protrusions, often linked with cell mobility in cancer systems. In this issue of Genes & Development, Norris and Mendell (pp. 191–203) systematically investigate a link between mRNA localization to cell protrusions in a mouse melanoma cell system and a mechanistic link to downstream consequences for cell mobility. The study first identifies a model mRNA of interest in an unbiased way that exhibits a set of phenotypes associated with cell mobility. The candidate mRNA that fulfills all requirements is Kif1c mRNA. Further systematic investigation links Kif1c mRNA localization to assembly of a protein–protein network on the KIF1C protein itself. What's clear is that this work will inspire a further mechanistic dissection of the Kif1c mRNA/KIF1C protein interplay in this important nonneuronal model cell system. More broadly, this work suggests that a broad set of model mRNAs should be investigated to understand mRNA dynamics and downstream functional consequences across a variety of cell models.

中文翻译：

---

这很复杂：Kif1c mRNA 在细胞突起中的定位、KIF1C 蛋白上蛋白结合伴侣的组装以及细胞迁移之间的相互作用


mRNA 的独特亚细胞定位已在多种细胞类型中得到描述。虽然神经元细胞出现了常见的主题，但在非神经元细胞中，mRNA 定位在空间和时间上的功能作用却知之甚少。令人感兴趣的新兴领域是具有突起的细胞模型，通常与癌症系统中的细胞流动性相关。在本期《基因与发育》中，Norris 和 Mendell（第 191-203 页）系统地研究了小鼠黑色素瘤细胞系统中 mRNA 定位与细胞突起之间的联系以及与细胞流动性下游后果的机制联系。该研究首先以公正的方式鉴定出感兴趣的模型 mRNA，该模型表现出一组与细胞迁移性相关的表型。满足所有要求的候选 mRNA 是Kif1c mRNA。进一步的系统研究将Kif1c mRNA 定位与 KIF1C 蛋白本身上蛋白质-蛋白质网络的组装联系起来。显而易见的是，这项工作将激发对这一重要的非神经元模型细胞系统中Kif1c mRNA/KIF1C 蛋白相互作用的进一步机制剖析。更广泛地说，这项工作表明应该研究广泛的模型 mRNA，以了解各种细胞模型中的 mRNA 动态和下游功能后果。