In this study, a cyclodextrin aqueous solution was used as an environmentally friendly eluent to simultaneously extract active and toxic compounds from food matrices with the aid of nanographite-assisted matrix solid phase dispersion microextraction (NG-MSPDM). The NG-MSPDM procedure was optimized by single-factor experiments and response surface methodology to obtain optimum conditions. The proposed method achieved excellent linearity at 0.10–20 μg/mL for all target analytes with a coefficient of correction (R²) ≥ 0.9909, limits of detection < 52.01 ng/mL, satisfactory reproducibility below 3.21 %, and acceptable recoveries of 82.0–112 %. To accurately determine the target components in the complex matrix, collision cross-section values of the analytes were obtained using ion mobility quadrupole time-of-flight mass spectrometry (IM-Q-TOF/MS). Results indicated that the NG-MSPDM method successfully achieved the simultaneous extraction of flavonoids and phenoxyacetic herbicides from Alpinia officinarum.

在这项研究中，使用环糊精水溶液作为环保洗脱液，借助纳米石墨辅助基质固相分散微萃取 (NG-MSPDM) 从食品基质中同时提取活性和有毒化合物。通过单因素实验和响应面方法优化 NG-MSPDM 程序以获得最佳条件。对于所有目标分析物，所提出的方法在 0.10–20 μg/mL 范围内实现了出色的线性，校正系数为 (R ²) ≥ 0.9909，检测限 < 52.01 ng/mL，令人满意的重现性低于 3.21%，可接受的回收率为 82.0–112%。为了准确确定复杂基质中的目标成分，使用离子淌度四极杆飞行时间质谱 (IM-Q-TOF/MS) 获得了分析物的碰撞截面值。结果表明，NG-MSPDM方法成功实现了良姜中黄酮类和苯氧乙酸类除草剂的同时提取。