Effects of Creatine Monohydrate on Endurance Performance in a Trained Population: A Systematic Review and Meta-analysis,Sports Medicine

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Effects of Creatine Monohydrate on Endurance Performance in a Trained Population: A Systematic Review and Meta-analysis
Sports Medicine ( IF 9.3 ) Pub Date : 2023-03-06 , DOI: 10.1007/s40279-023-01823-2
Julen Fernández-Landa _{1,

2} , Asier Santibañez-Gutierrez _{1,

2} , Nikola Todorovic ₂ , Valdemar Stajer ₂ , Sergej M Ostojic _{2,

3}

Affiliation

Background

There is robust evidence that creatine monohydrate supplementation can enhance short-term high-intensity exercise in athletes. However, the effect of creatine monohydrate supplementation on aerobic performance and its role during aerobic activities is still controversial.

Objective

The purpose of this systematic review and meta-analysis was to evaluate the supplementation effects of creatine monohydrate on endurance performance in a trained population.

Methods

The search strategy in this systematic review and meta-analysis was designed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and PubMed/MEDLINE, Web of Science, and Scopus databases were explored from inception until 19 May, 2022. Only human experimental trials, controlled with a placebo group, evaluating the effects of creatine monohydrate supplementation on endurance performance in a trained population were analyzed in this systematic review and meta-analysis. The methodological quality of included studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale.

Results

A total of 13 studies satisfied all the eligibility criteria and were included in this systematic review and meta-analysis. The results for the pooled meta-analysis showed a non-significant change in endurance performance after creatine monohydrate supplementation in a trained population (p = 0.47), with a trivial negative effect (pooled standardized mean difference = − 0.07 [95% confidence interval − 0.32 to 0.18]; I² = 34.75%). Further, after excluding the studies not evenly distributed around the base of the funnel plot, the results were similar (pooled standardized mean difference = − 0.07 [95% confidence interval − 0.27 to 0.13]; I² = 0%; p = 0.49).

Conclusions

Creatine monohydrate supplementation was shown to be ineffective on endurance performance in a trained population.

Clinical Trial Registration

The study protocol was registered in the Prospective Register of Systematic Review (PROSPERO) with the following registration number: CRD42022327368.

中文翻译：

一水肌酸对训练人群耐力表现的影响：系统评价和荟萃分析

背景

有确凿证据表明补充一水肌酸可以增强运动员的短期高强度运动。然而，补充一水肌酸对有氧运动能力的影响及其在有氧运动中的作用仍存在争议。

客观的

本系统评价和荟萃分析的目的是评估补充一水肌酸对受过训练的人群的耐力表现的影响。

方法

本系统评价和荟萃分析中的搜索策略是根据系统评价和荟萃分析 (PRISMA) 指南的首选报告项目设计的，并且从开始到 2022 年 5 月 19 日对 PubMed/MEDLINE、Web of Science 和 Scopus 数据库进行了探索. 在此系统评价和荟萃分析中，仅分析了以安慰剂组为对照的人体实验试验，以评估补充一水肌酸对受过训练的人群的耐力表现的影响。使用物理治疗证据数据库 (PEDro) 量表评估纳入研究的方法学质量。

结果

共有 13 项研究满足所有资格标准，并被纳入本系统评价和荟萃分析。汇总荟萃分析的结果显示，在受过训练的人群中补充一水肌酸后，耐力表现没有显着变化（p = 0.47），负面影响很小（汇总标准化均值差 = − 0.07 [95% 置信区间 − 0.32 至 0.18]；I ² = 34.75%）。此外，在排除未均匀分布在漏斗图底部的研究后，结果相似（汇总标准化平均差 = − 0.07 [95% 置信区间 − 0.27 至 0.13]；I 2 = 0% ；^p = 0.49 ） .