Development of axially chiral urazole scaffolds for antiplant virus applications against potato virus Y,Pest Management Science

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Development of axially chiral urazole scaffolds for antiplant virus applications against potato virus Y
Pest Management Science ( IF 3.8 ) Pub Date : 2023-03-02 , DOI: 10.1002/ps.7428
Jiamiao Jin ₁ , Chengli Mou ₂ , Juan Zou ₂ , Xin Xie ₃ , Chen Wang ₁ , Tingwei Shen ₁ , Youlin Deng ₁ , Benpeng Li ₁ , Zhichao Jin ₁ , Xiangyang Li ₁ , Yonggui Robin Chi _{1,

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Affiliation

Potato virus Y (PVY) was first discovered by Smith in 1931 and is currently ranked as the fifth most significant plant virus. It can cause severe damage to plants from the family Solanaceae, which results in billions of dollars of economic loss worldwide every year. To discover new antiviral drugs, a class of multifunctional urazole derivatives bearing a stereogenic CN axis were synthesized with excellent optical purities for antiviral evaluations against PVY.

中文翻译：

用于抗植物病毒抗马铃薯病毒 Y 的轴向手性乌拉唑支架的开发

马铃薯 Y 病毒(PVY) 于 1931 年由 Smith 首次发现，目前被列为第五大最重要的植物病毒。它可以对茄科植物造成严重损害，每年在全球造成数十亿美元的经济损失。为了发现新的抗病毒药物，合成了一类具有立体异构 C  N 轴的多功能乌拉唑衍生物，具有优异的光学纯度，用于对 PVY 的抗病毒评价。

更新日期：2023-03-02

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