The polyetheretherketone (PEEK)-highly cross-linked polyethylene (XLPE), all-polymer knee prosthesis has excellent prospects for replacing the traditional metal/ceramic-polyethylene joint prosthesis, improving the service life of the joint prosthesis and the quality of patients’ life. The long-term wear mechanism of PEEK-XLPE knee joint prosthesis is comprehensively evaluated from wear amount, wear morphology, and wear debris compared to that of CoCrMo-XLPE joint prosthesis. After 5 million cycles of in vitro wear, the wear loss of XLPE in PEEK-XLPE (30.9±3.2 mg) is lower than that of XLPE in CoCrMo-XLPE (32.1±3.1 mg). Compared to the XLPE in CoCrMo-XLPE, the plastic deformation of XLPE in PEEK-XLPE is more severe in the early stage, and the adhesive peeling and adhesion are lighter in the later stage. The size distribution of XLPE wear debris in PEEK-XLPE is relatively dispersed, which in CoCrMo-XLPE is relatively concentrated. Wear debris is mainly flake and block debris, and the wear mechanism of XLPE was abrasive wear. The wear volume per unit area of PEEK femoral condyle (10.45×10⁵ µm³/mm²) is higher than that of CoCrMo (8.32×10⁵ µm³/mm²). The PEEK surface is mainly furrows and adhesions, while the CoCrMo surface is mainly furrows and corrosion spots. The PEEK wear debris is mainly in flakes and blocks, and the CoCrMo wear debris is mainly in the shape of rods and blocks. The wear mechanism of PEEK is abrasive wear and adhesion, and that of CoCrMo is abrasive wear and corrosion.

聚醚醚酮（PEEK）-高交联聚乙烯（XLPE）全聚合物膝关节假体具有替代传统金属/陶瓷-聚乙烯关节假体的良好前景，提高关节假体的使用寿命和患者的生活质量。与CoCrMo-XLPE膝关节假体相比，从磨损量、磨损形态、磨屑等方面综合评价PEEK-XLPE膝关节假体的长期磨损机制。经过500万次体外循环后磨损情况下，PEEK-XLPE中XLPE的磨损量（30.9±3.2 mg）低于CoCrMo-XLPE中XLPE的磨损量（32.1±3.1 mg）。与CoCrMo-XLPE中的XLPE相比，PEEK-XLPE中XLPE的塑性变形前期较严重，后期胶粘剂剥离和粘连较轻。PEEK-XLPE中XLPE磨屑的尺寸分布相对分散，而CoCrMo-XLPE中XLPE磨屑的尺寸分布相对集中。磨损碎片主要为片状和块状碎片，XLPE的磨损机制为磨粒磨损。PEEK股骨髁单位面积磨损量（10.45×10 ⁵ µm ³ /mm ²）高于CoCrMo股骨髁单位面积磨损量（8.32×10 ⁵ µm ³ /mm ^{2 ）}）。PEEK表面主要是皱纹和粘连，而CoCrMo表面主要是皱纹和腐蚀点。PEEK磨屑主要呈片状和块状，CoCrMo磨屑主要呈棒状和块状。PEEK的磨损机理是磨粒磨损和粘着，CoCrMo的磨损机理是磨粒磨损和腐蚀。