Making an important scientific discovery is just the first step in a process. One also needs to communicate that scientific discovery and its impact, and get it accepted into the mainstream of research in order to advance a field. Communicating discoveries is where scientific journals play a critical role through their implementation of the peer review process and dissemination of the findings. This process is imperfect for a variety of reasons. Most commonly, journal editors and reviewers that assess manuscripts for publication can fail to appreciate findings, especially when they go against the current accepted views of a given field. While you might expect scientists, including editors and reviewers, to be open-minded about new discoveries that alter the trajectory of a field, all to commonly they are not. Many are risk-adverse or lack sufficient depth of knowledge to assess paradigm shifts. Throughout my career, I and my collaborators and colleagues have encountered this obstacle in publishing. This is where an exceptional journal editor, Terri Grodzicker, at the helm of Genes & Development for 35 years, made remarkable and lasting contributions to science. Her ability to recognize paradigm-shifting work, identify exceptional reviewers of the same ilk, and make the appropriate interpretations of the manuscript reviews drove impactful science forward. I am greatly indebted to Terri for the intellectual capacity, vision, and boldness to recognize these major paradigm shifts, first in the field of apoptosis and later in autophagy. G&D published many but not all of our papers that are now accepted mainstays with thousands of citations and clinical impact for cancer treatment.

中文翻译：

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细胞凋亡、自噬和癌症：基因与发育在范式转变中发挥的关键作用

做出重要的科学发现只是整个过程的第一步。人们还需要交流该科学发现及其影响，并使其被主流研究接受，以推动一个领域的发展。传播发现是科学期刊通过实施同行评审过程和传播发现发挥关键作用的地方。由于各种原因，这个过程并不完美。最常见的是，评估发表手稿的期刊编辑和审稿人可能无法欣赏研究结果，尤其是当它们与特定领域当前公认的观点相悖时。虽然您可能希望科学家（包括编辑和审稿人）对改变某个领域轨迹的新发现持开放态度，但通常情况并非如此。许多人规避风险或缺乏足够的知识深度来评估范式转变。在我的整个职业生涯中，我和我的合作者和同事在出版方面都遇到过这个障碍。这是杰出的期刊编辑 Terri Grodzicker 掌舵的地方Genes & Development 35 年，为科学做出了卓越而持久的贡献。她能够识别范式转变的工作，识别同类的杰出审稿人，并对手稿评论做出适当的解释，推动有影响力的科学向前发展。我非常感谢 Terri 的智力、远见和勇气，让我认识到这些主要的范式转变，首先是在细胞凋亡领域，然后是自噬领域。G&D发表了很多但不是我们所有的论文，这些论文现在被接受为中流砥柱，被引用数以千计，对癌症治疗具有临床影响。