BACKGROUND Alcohol use disorder (AUD) is a widespread mental disorder and has thrust a heavy burden on the health system all over the world. Social cognition and function are reported to be impaired in AUD, but its neural mechanism is rarely investigated. The current study attempts to fill this gap. METHODS 28 subjects with AUD and 36 healthy controls (HC) were recruited in this study and were paired into 14 AUD dyads and 18 HC dyads. The drinking problems, depression, anxiety, and impulsivity of subjects were measured. Each dyad completed cooperation and competition tasks with simultaneous frontal functional near-infrared spectroscopy (fNIRS) hyperscanning recording. The inter-brain synchronization (IBS) in the frontal cortex was calculated for each dyad and compared between AUD and HC. The significantly altered IBS in AUD was correlated with clinical measures to explore possible influencing factors. RESULTS The IBS in the right middle frontal cortex was significantly decreased in AUD under both cooperation (t = -2.257, P = 0.028) and competition (t = -2.488, P = 0.016) task. The IBS during the cooperation task in the right middle frontal cortex in AUD was negatively correlated with non-planning impulsivity (r = -0.673, P = 0.006). LIMITATIONS This study used cross-sectional data, which limited the causal inference. The synchronization between other brain regions besides the frontal cortex should be further explored in patients with AUD. CONCLUSION The current study could provide new insights into the neural mechanism of social dysfunction in AUD and facilitate clinical intervention in future practice.

中文翻译：

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社交互动期间酒精使用障碍患者右中额叶皮层的脑间同步减少：一项 fNIRS 超扫描研究。

背景技术酒精使用障碍(AUD)是一种普遍存在的精神障碍，给全世界的卫生系统带来了沉重的负担。据报道，AUD 的社会认知和功能受损，但其神经机制很少被研究。目前的研究试图填补这一空白。方法 本研究招募了 28 名 AUD 受试者和 36 名健康对照 (HC)，并分为 14 名 AUD 组和 18 名 HC 组。测量了受试者的饮酒问题、抑郁、焦虑和冲动。每个双人组都通过同步额功能近红外光谱（fNIRS）超扫描记录完成合作和竞争任务。计算每个二元组的额叶皮层脑间同步（IBS），并在 AUD 和 HC 之间进行比较。AUD 中 IBS 的显着改变与临床测量相关，以探索可能的影响因素。结果在合作任务（t = -2.257，P = 0.028）和竞争任务（t = -2.488，P = 0.016）下，AUD 中右额叶皮质中的 IBS 均显着降低。AUD中右中额叶皮层合作任务期间的IBS与非计划冲动呈负相关（r = -0.673，P = 0.006）。局限性本研究使用横截面数据，限制了因果推断。在 AUD 患者中，除了额叶皮层之外，其他大脑区域之间的同步性还应该进一步探索。结论当前的研究可以为AUD社会功能障碍的神经机制提供新的见解，并有助于未来实践中的临床干预。