儿童鼻腔一氧化氮测量诊断原发性纤毛运动障碍：欧洲呼吸学会技术标准,European Respiratory Journal

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儿童鼻腔一氧化氮测量诊断原发性纤毛运动障碍：欧洲呼吸学会技术标准
European Respiratory Journal ( IF 16.6 ) Pub Date : 2023-04-20 , DOI: 10.1183/13993003.02031-2022
Nicole Beydon _{1,

2,

3} , Panayiotis Kouis ₄ , June K Marthin ₅ , Philipp Latzin ₆ , Murielle Colas ₇ , Stephanie D Davis ₈ , Eric Haarman ₉ , Amanda Lea Harris _{10,

11} , Claire Hogg ₁₂ , Emma Kilbride ₁₃ , Claudia E Kuehni _{6,

14} , Diana Marangu ₁₅ , Kim G Nielsen _{5,

16} , Catherine Pendergrast _{17,

18} , Phil Robinson _{19,

20,

21} , Nisreen Rumman _{22,

23} , Matthew Rutter ₂₄ , Woolf T Walker _{10,

11} , Thomas Ferkol ₈ , Jane S Lucas _{3,

11,

25}

Affiliation

AP-HP, Sorbonne Université, Unité Fonctionnelle de Physiologie - Explorations Fonctionnelles Respiratoires et du Sommeil, Hôpital Armand Trousseau, Paris, France.
Sorbonne Université, INSERM U938, Centre de Recherche Saint-Antoine, Hôpital Saint-Antoine, Paris, France.
N. Beydon and J.S. Lucas co-chaired the Task Force and contributed equally.
Respiratory Physiology Laboratory, Medical School, University of Cyprus, Nicosia, Cyprus.
Danish PCD Centre Copenhagen, Paediatric Pulmonary Service, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Division of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Parent Representative, Paris, France.
Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, UNC Children's, Chapel Hill, NC, USA.
Department of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Primary Ciliary Dyskinesia Centre, NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton, Southampton, UK.
Department of Paediatric Respiratory Medicine and Primary Ciliary Dyskinesia Centre, Royal Brompton Hospital, Imperial College London, London, UK.
Paediatric Respiratory Laboratory, Children's Health Ireland, Dublin, Ireland.
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Lung Function Laboratory, Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, Adelaide, Australia.
Innovation, Implementation and Clinical Translation in Health (IIMPACT) Research Concentration, University of South Australia, Adelaide, Australia.
Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Australia.
Department of Paediatrics, University of Melbourne, Parkville, Australia.
Murdoch Children's Research Institute, Parkville, Australia.
Department of Pediatrics, Makassed Hospital, Al-Quds University, East Jerusalem, Palestine.
Caritas Baby Hospital, Bethlehem, Palestine.
Lung Function Department, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.
Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK

大多数原发性纤毛运动障碍 (PCD) 患者的鼻腔一氧化氮 (nNO) 含量极低，其测量值是做出诊断的重要因素。现有指南和技术标准侧重于使用化学发光分析仪对年龄较大、合作的儿童进行 nNO 测量。然而，学龄前儿童（2-5 岁）的 nNO 测量可能有助于早期诊断，电化学而非化学发光分析仪被广泛使用。学龄前儿童在测量 nNO 时通常需要采用不同的方法。因此，欧洲呼吸学会工作组制定了这项技术标准，作为标准化 nNO 的采样、分析和报告的第一步，作为所有年龄组（包括学龄前儿童）PCD 诊断测试的一部分。此外，我们考虑了全球使用的化学发光和电化学分析仪。用于幼儿的电化学分析仪和采样方法缺乏质量证据，工作组提出了未来的研究重点，以允许更新该技术标准。

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更新日期：2023-04-20

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