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Development of Smartphone-Controlled and Microneedle-Based Wearable Continuous Glucose Monitoring System for Home-Care Diabetes Management
ACS Sensors ( IF 8.2 ) Pub Date : 2023-02-23 , DOI: 10.1021/acssensors.2c02635 Jian Yang 1 , Xia Gong 1 , Shuijin Chen 1 , Ying Zheng 1 , Lelun Peng 1 , Bin Liu 1 , Zhipeng Chen 1 , Xi Xie 2 , Changqing Yi 1, 3 , Lelun Jiang 1, 3
ACS Sensors ( IF 8.2 ) Pub Date : 2023-02-23 , DOI: 10.1021/acssensors.2c02635 Jian Yang 1 , Xia Gong 1 , Shuijin Chen 1 , Ying Zheng 1 , Lelun Peng 1 , Bin Liu 1 , Zhipeng Chen 1 , Xi Xie 2 , Changqing Yi 1, 3 , Lelun Jiang 1, 3
Affiliation
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Continuous glucose monitoring (CGM) can mini-invasively track blood glucose fluctuation and reduce the risk of hyperglycemia and hypoglycemia, and this is is in great demand for diabetes management. However, cost-effective manufacture of CGM systems with continuously improved convenience and performance is still the persistent goal. Herein, we developed a smartphone-controlled and microneedle (MN)-based wearable CGM system for long-term glucose monitoring. The CGM system modified with a sandwich-type enzyme immobilization strategy can satisfy the clinical requirement of interstitial fluid (ISF) glucose monitoring for 14 days with a mean absolute relative difference of 10.2% and a cost of less than $15, which correlated well with the commercial glucometer and FDA-approved CGM system FreeStyle Libre (Abbott Inc., Illinois, USA). The self-developed CGM system is demonstrated to accurately monitor glucose fluctuations and provide abundant clinical information. It is better to find the cause of individual blood glucose changes and beneficial for the guide of precise glucose control. On the whole, the intelligently wearable CGM system may provide an alternative solution for home-care diabetes management.
中文翻译：
开发用于家庭护理糖尿病管理的智能手机控制和基于微针的可穿戴连续血糖监测系统
连续血糖监测（CGM）可以微创跟踪血糖波动，降低高血糖和低血糖的风险，这对糖尿病管理有很大的需求。然而，具有持续改进的便利性和性能的具有成本效益的 CGM 系统制造仍然是一个持久的目标。在此，我们开发了一种用于长期血糖监测的智能手机控制和基于微针 (MN) 的可穿戴 CGM 系统。采用夹心式酶固定化策略改造的CGM系统可以满足间质液（ISF）血糖监测14天的临床需求，平均绝对相对差为10.2%，成本低于15美元，与商用血糖仪和 FDA 批准的 CGM 系统 FreeStyle Libre（美国伊利诺伊州雅培公司）。自主研发的CGM系统被证明可以准确监测血糖波动并提供丰富的临床信息。更好地找到个体血糖变化的原因，有利于指导精准血糖控制。总体而言，智能可穿戴 CGM 系统可能为家庭护理糖尿病管理提供替代解决方案。
更新日期：2023-02-23
中文翻译：
开发用于家庭护理糖尿病管理的智能手机控制和基于微针的可穿戴连续血糖监测系统
连续血糖监测（CGM）可以微创跟踪血糖波动，降低高血糖和低血糖的风险，这对糖尿病管理有很大的需求。然而，具有持续改进的便利性和性能的具有成本效益的 CGM 系统制造仍然是一个持久的目标。在此，我们开发了一种用于长期血糖监测的智能手机控制和基于微针 (MN) 的可穿戴 CGM 系统。采用夹心式酶固定化策略改造的CGM系统可以满足间质液（ISF）血糖监测14天的临床需求，平均绝对相对差为10.2%，成本低于15美元，与商用血糖仪和 FDA 批准的 CGM 系统 FreeStyle Libre（美国伊利诺伊州雅培公司）。自主研发的CGM系统被证明可以准确监测血糖波动并提供丰富的临床信息。更好地找到个体血糖变化的原因，有利于指导精准血糖控制。总体而言，智能可穿戴 CGM 系统可能为家庭护理糖尿病管理提供替代解决方案。
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