Background

Researchers have documented that adverse childhood experiences (ACEs) are associated with adverse long-term consequences for mental health, including increased risk for depression. However, the type and dose-response effects of ACE on depression risk need further exploration.

Objective

We aimed to synthesize the evidence on the relationship between ACEs measured by ACE International Questionnaire (ACE-IQ) and depression in type and quantity.

Participants and setting

Individuals with ACEs.

Methods

A systematic search was carried out of all published articles, up to November 2022, in eight electronic databases. Fixed- and random-effect models and dose-response were used.

Results

Exposure to ACEs, including household dysfunction, was associated with a higher risk of depression (ORs ranged from 1.34 to 3.17). The numbers of ACE acted as a nonlinear predictor of depression.

Conclusions

These analyses provided important evidence that ACEs, regardless of type or quantity, may be a risk factor for depression development. Prevention of ACEs and interventions for supporting those affected by ACEs are necessary.

中文翻译：

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不良童年经历对预测抑郁症的类型和剂量反应效应：系统评价和荟萃分析

背景

研究人员已经证明，不良的童年经历 (ACE) 与心理健康的长期不良后果有关，包括增加患抑郁症的风险。然而，ACE 对抑郁症风险的类型和剂量反应效应需要进一步探索。

客观的

我们的目的是综合有关 ACE 国际问卷 (ACE-IQ) 测量的 ACE 与抑郁类型和数量之间关系的证据。

参与者和设置

拥有 ACE 的个人。

方法

在八个电子数据库中对截至 2022 年 11 月的所有已发表文章进行了系统搜索。使用固定和随机效应模型以及剂量反应。

结果

接触 ACE，包括家庭功能障碍，与更高的抑郁风险相关（OR 范围从 1.34 到 3.17）。ACE 的数量充当抑郁症的非线性预测因子。

结论

这些分析提供了重要证据表明，无论类型或数量如何，ACE 都可能是抑郁症发展的危险因素。预防 ACE 和支持受 ACE 影响的人的干预措施是必要的。