Tissue porosity pressure mechanics play a vital role in the physiological workings and anatomical structures of soft tissue. Further understanding relationships between the pressurized state of the tissue and its function by noninvasive measurements may lead to new diagnostic methods for identifying early stages of disease pathology. The purpose of this study was to investigate the ability of Magnetic Resonance Elastography (MRE) to identify mechanics related to different pressurized states of porous soft tissue-like media. Phantoms with variations in stiffness and porous network geometries are scanned with MRE at 9.4 Tesla while pore pressure is quasi-statically loaded with 0, 50, 100, 150 mmHg gauge using air and liquid pressure. The MRE-derived shear modulus of tissue around isolated pores correlates with pore pressure. However, this was not observed for interconnected porous systems, in which the shear wavelength is much larger than the distance between neighboring pore branches. In these systems, the presented experimental results highlight the importance of a compressibility marker derived from 3D MRE acquisitions, which may be sensitive to pore pressure and pore network geometry.

组织孔隙压力力学在软组织的生理工作和解剖结构中起着至关重要的作用。通过无创测量进一步了解组织的加压状态与其功能之间的关系，可能会产生用于识别疾病病理学早期阶段的新诊断方法。本研究的目的是研究磁共振弹性成像 (MRE) 识别与多孔软组织样介质的不同加压状态相关的力学的能力。在 9.4 特斯拉下使用 MRE 扫描具有刚度和多孔网络几何形状变化的体模，同时使用空气和液体压力以 0、50、100、150 mmHg 计准静态加载孔隙压力。孤立孔隙周围组织的 MRE 衍生剪切模量与孔隙压力相关。然而，对于相互连接的多孔系统没有观察到这一点，其中剪切波长远大于相邻孔隙分支之间的距离。在这些系统中，所呈现的实验结果强调了从 3D MRE 采集中得出的可压缩性标记的重要性，它可能对孔隙压力和孔隙网络几何形状敏感。