Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3·9H2O,Organic Process Research & Development

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Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3·9H2O
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2023-02-12 , DOI: 10.1021/acs.oprd.2c00390
Kai Liu ₁ , Jiaolong Meng ₁ , Xuefeng Jiang _{1,

2,

3}

Affiliation

Sulfoxides, as an essential pivot, are commonly found in pharmaceuticals and bulk chemicals. A practical synthetic protocol is depicted via application of readily obtainable Fe(NO₃)₃·9H₂O as a catalyst and oxygen as a green oxidant for selective oxidation from thioethers to sulfoxides under ecofriendly and mild conditions. Various sulfoxides are all achieved in gram-scale with superior selectivity and efficiency. This protocol showcases broad-spectrum functional group compatibility, offering efficient access to sulfoxide construction for drug discovery and process optimization.

中文翻译：

Fe(NO3)3·9H2O 催化氧气克级合成亚砜

亚砜作为一种重要的枢纽，常见于药品和散装化学品中。描述了通过应用容易获得的Fe(NO ₃ ) ₃ ·9H ₂ O作为催化剂和氧气作为绿色氧化剂在环保和温和的条件下将硫醚选择性氧化为亚砜的实际合成方案。各种亚砜均达到克级水平，具有卓越的选择性和效率。该协议展示了广谱官能团兼容性，为药物发现和工艺优化提供了有效的亚砜结构。

更新日期：2023-02-12

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