当前位置: X-MOL 学术Friction › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis
Friction ( IF 6.3 ) Pub Date : 2023-02-11 , DOI: 10.1007/s40544-022-0710-x
Yi Wang , Weijie Zhai , Shujie Cheng , Jinghua Li , Hongyu Zhang

The anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomaterials is a classic problem in tribological research, as both antithrombotic and hemostatic materials are closely associated with this problem. Thrombus formation on the surfaces of blood-contacting biomedical devices can detrimentally affect their performance and patient life, so specific surface functionalization is required. Currently, intensive research has focused on the development of super-lubricated or super-hydrophobic coatings, as well as coatings that deliver antithrombotic drugs. In addition, hemostatic biomaterials with porous structures, biochemical substances, and strongly adhesive hydrogels can be used to achieve rapid and effective hemostasis via physical or biochemical mechanisms. This article reviews methods of preparing anticoagulant coatings on material surfaces and the current status of rapid hemostatic materials. It also summarizes fundamental concepts for the design and synthesis of anticoagulant and hemostatic materials by discussing thrombosis and hemostasis mechanisms in biomedical devices and normal organisms. Because there are relatively few reports reviewing the progress in surface-functionalized design for anticoagulation and hemostasis, it is anticipated that this review can provide a useful summary of the applications of both bio-adhesion and bio-lubrication techniques in the field of biomedical engineering.



中文翻译:

防凝促止血接血生物材料的表面功能化设计

接血材料的抗凝和止血性能是相反的研究方向,但它们的实现机制却相互启发。血液和植入式生物材料之间的接触是摩擦学研究中的一个经典问题,因为抗血栓和止血材料都与这个问题密切相关。血液接触生物医学设备表面形成的血栓会对它们的性能和患者寿命产生不利影响,因此需要特定的表面功能化。目前,深入的研究集中在开发超润滑或超疏水涂层,以及提供抗血栓药物的涂层。此外,具有多孔结构的止血生物材料、生化物质、强粘附水凝胶可用于通过物理或生化机制实现快速有效的止血。本文综述了材料表面抗凝涂层的制备方法及快速止血材料的现状。它还通过讨论生物医学设备和正常生物体中的血栓形成和止血机制,总结了抗凝剂和止血材料的设计和合成的基本概念。由于综述抗凝止血表面功能化设计进展的报道相对较少,预计本综述可以为生物粘附和生物润滑技术在生物医学工程领域的应用提供有用的总结。本文综述了材料表面抗凝涂层的制备方法及快速止血材料的现状。它还通过讨论生物医学设备和正常生物体中的血栓形成和止血机制,总结了抗凝剂和止血材料的设计和合成的基本概念。由于综述抗凝止血表面功能化设计进展的报道相对较少,预计本综述可以为生物粘附和生物润滑技术在生物医学工程领域的应用提供有用的总结。本文综述了材料表面抗凝涂层的制备方法及快速止血材料的现状。它还通过讨论生物医学设备和正常生物体中的血栓形成和止血机制,总结了抗凝剂和止血材料的设计和合成的基本概念。由于综述抗凝止血表面功能化设计进展的报道相对较少,预计本综述可以为生物粘附和生物润滑技术在生物医学工程领域的应用提供有用的总结。它还通过讨论生物医学设备和正常生物体中的血栓形成和止血机制,总结了抗凝剂和止血材料的设计和合成的基本概念。由于综述抗凝止血表面功能化设计进展的报道相对较少,预计本综述可以为生物粘附和生物润滑技术在生物医学工程领域的应用提供有用的总结。它还通过讨论生物医学设备和正常生物体中的血栓形成和止血机制,总结了抗凝剂和止血材料的设计和合成的基本概念。由于综述抗凝止血表面功能化设计进展的报道相对较少,预计本综述可以为生物粘附和生物润滑技术在生物医学工程领域的应用提供有用的总结。

更新日期:2023-02-11
down
wechat
bug