Coronary artery tortuosity (CAT) is frequently detected during coronary angiography or coronary electron-beam computed tomography angiography by cardiovascular interventionalists. In this article, we described the case of a 69-year-old female patient with recurrent chest discomfort for 1 month and recurrence 1 week ago, accompanied by emaciation, gastrointestinal discomfort, and low skin temperature at the extremities. After a series of tests, the patient was finally diagnosed with severe CAT and coexisting connective tissue disease. Accordingly, she was treated with conventional medications, and diet and lifestyle modifications. The symptoms of the patient resolved gradually after 1 year of follow-up. Although there is no unanimous conclusion on the pathogenesis and clinical characteristics of CAT, this disease may provide a clue to the diagnosis of connective tissue disease, and warrants exploration through further research.

中文翻译：

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严重冠状动脉迂曲并存结缔组织病一例报告

心血管介入医生在冠状动脉造影或冠状动脉电子束计算机断层扫描血管造影期间经常检测到冠状动脉迂曲（CAT）。本文描述一例69岁女性患者，反复胸部不适1个月，1周前复发，伴有消瘦、胃肠不适、四肢皮温低。经过一系列检查，患者最终被诊断为重症CAT并合并结缔组织病。因此，她接受了常规药物治疗以及饮食和生活方式的改变。随访1年后，患者症状逐渐缓解。尽管对于CAT的发病机制和临床特点尚无一致结论，