Amyloids have special structural properties and are involved in many aspects of biological function. In particular, amyloids are the cause or hallmarks of a group of notorious and incurable neurodegenerative diseases. The extraordinary high molecular weight and aggregation states of amyloids have posed a challenge for researchers studying them. Solid-state NMR (SSNMR) has been extensively applied to study the structures and dynamics of amyloids for the past 20 or more years and brought us tremendous progress in understanding their structure and related diseases. These studies, at the same time, helped to push SSNMR technical developments in sensitivity and resolution. In this review, some interesting research studies and important technical developments are highlighted to give the reader an overview of the current state of this field.

淀粉样蛋白具有特殊的结构特性，并参与生物学功能的许多方面。特别是，淀粉样蛋白是一组臭名昭著且无法治愈的神经退行性疾病的原因或标志。淀粉样蛋白的超高分子量和聚集状态给研究它们的研究人员带来了挑战。固态核磁共振 (SSNMR) 在过去 20 多年中被广泛应用于研究淀粉样蛋白的结构和动力学，并使我们在了解其结构和相关疾病方面取得了巨大进展。同时，这些研究有助于推动 SSNMR 在灵敏度和分辨率方面的技术发展。在这篇综述中，重点介绍了一些有趣的研究和重要的技术发展，以向读者提供该领域当前状态的概览。