Mature non-Hodgkin lymphomas (NHL) in the childhood, adolescent and young adult (CAYA) population are rare and exhibit unique clinical, immunophenotypic and genetic characteristics. Application of large-scale unbiased genomic and proteomic technologies such as gene expression profiling and next generation sequencing (NGS) have led to enhanced understanding of the genetic basis for many lymphomas in adults. However, studies to investigate the pathogenetic events in CAYA population are relatively sparse. Enhanced understanding of the pathobiologic mechanisms involved in non-Hodgkin lymphomas in this unique population will allow for improved recognition of these rare lymphomas. Elucidation of the pathobiologic differences between CAYA and adult lymphomas will also lead to the design of more rational and much needed, less toxic therapies for this population. In this review, we summarize recent insights gained from the proceedings of the recent 7th International CAYA NHL Symposium held in New York City, New York October 20–23, 2022.

儿童、青少年和青年 (CAYA) 人群中的成熟非霍奇金淋巴瘤 (NHL) 很少见，并表现出独特的临床、免疫表型和遗传特征。基因表达谱分析和下一代测序 (NGS) 等大规模无偏基因组学和蛋白质组学技术的应用加深了人们对许多成人淋巴瘤遗传基础的理解。然而，调查 CAYA 人群致病事件的研究相对较少。加强对这一独特人群中非霍奇金淋巴瘤所涉及的病理生物学机制的了解，将有助于提高对这些罕见淋巴瘤的认识。阐明 CAYA 和成人淋巴瘤之间的病理生物学差异也将导致更合理和更需要的设计，对这一人群的毒性较小的疗法。在这篇评论中，我们总结了最近从 2022 年 10 月 20 日至 23 日在纽约纽约市举行的第七届国际 CAYA NHL 研讨会的会议记录中获得的最新见解。