In this issue of Structure, Wang et al. investigate the interplay between folded and disordered regions of the SARS-CoV-2 non-structural protein 1 (Nsp1) that promotes the suppression of host protein translation. Their investigation will lead to novel avenues to therapeutically target critical viral functions necessary for host immune-response suppression.

中文翻译：

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SARS-CoV-2 Nsp1 中的有序和无序结合在一起抑制宿主翻译

在本期结构中，Wang 等人。研究 SARS-CoV-2 非结构蛋白 1 (Nsp1) 折叠区和无序区之间的相互作用，促进宿主蛋白翻译的抑制。他们的研究将开辟新的途径来治疗靶向宿主免疫反应抑制所必需的关键病毒功能。