Enzymatic cis-Decalin Formation in Natural Product Biosynthesis,Journal of the American Chemical Society

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Enzymatic cis-Decalin Formation in Natural Product Biosynthesis
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-02-01 , DOI: 10.1021/jacs.2c12854
Masao Ohashi , Dan Tan ₁ , Jiayan Lu ₂ , Cooper S Jamieson , Daiki Kanayama , Jiahai Zhou ₂ , K N Houk , Yi Tang

Affiliation

Stereoselective synthesis of cis-decalin structures using [4 + 2] cycloaddition is challenging. We explored the biosynthetic pathway of the fungal natural product fischerin (1) to identify a new pericyclase FinI that can catalyze such a reaction. The cocrystal structure of FinI, a predicted O-methyltransferase, with the product and SAM provides insight into cis-decalin formation in nature.

中文翻译：

天然产物生物合成中酶促顺式十氢化萘的形成

使用[4 + 2]环加成立体选择性合成顺式十氢化萘结构具有挑战性。我们探索了真菌天然产物 fischerin ( 1 )的生物合成途径，以确定一种可以催化此类反应的新周环化酶 FinI。FinI（一种预测的O-甲基转移酶）与产物和 SAM的共晶结构提供了对自然界顺式十氢萘形成的深入了解。

更新日期：2023-02-01

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