Contraction of the hair follicle-lining dermal sheath smooth muscle generates the forces necessary for the tissue remodelling that takes place during the regression phase of the hair growth cycle. This study reveals that endothelin signalling — from epithelial progenitors at the follicle bottleneck region to its neighbouring dermal sheath — is the main contraction-activating pathway.

中文翻译：

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内皮素信号驱动毛囊退化的真皮鞘平滑肌收缩

毛囊衬里真皮鞘平滑肌的收缩产生在毛发生长周期的退化阶段发生的组织重塑所必需的力。这项研究表明，内皮素信号——从卵泡瓶颈区域的上皮祖细胞到其邻近的真皮鞘——是主要的收缩激活途径。