Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Continuous administration of steroids often causes undesired side effects; hence, drug delivery systems with high loading capacities and sustained release profiles are required. Herein, adhesive hydrogels for sustained transdermal delivery of dexamethasone (DEX), a potent corticosteroid, have been suggested for AD treatment. The adhesive composite hydrogels comprise a double network of polyacrylamide (PAM) and polydopamine (PDA) embedded with extra-large-pore mesoporous silica nanoparticles (XL-MSNs). The intrinsic skin adhesiveness of the dopamine-derived PAM/PDA hydrogels is further enhanced by XL-MSN incorporation that contributes to the simultaneous enhancement of cohesion and adhesion of the hydrogel. The resulting adhesive hydrogels exhibit a high water content and strong adhesion to porcine skin. A sustained release of DEX is obtained when DEX is loaded within the pores of XL-MSNs in PAM/PDA hydrogels compared to the rapid release from the direct loading of DEX in hydrogels. Application of DEX-loaded MSN@PAM/PDA hydrogels on an AD mouse model led to the significant suppression of AD symptoms, including the restoration of the thickened epidermal layer, decrease in inflammatory cell infiltration in the skin, recovery of collagen deposition, and decreased levels of immunoglobulin E. XL-MSN-embedded adhesive hydrogels could be a potential platform for topical drug delivery to treat inflammatory skin diseases.

中文翻译：

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用于持续透皮给药治疗特应性皮炎的粘性复合水凝胶贴剂

特应性皮炎（AD）是一种常见的慢性炎症性皮肤病。连续服用类固醇通常会引起不良副作用；因此，需要具有高负载能力和持续释放特性的药物输送系统。在此，用于持续透皮递送地塞米松 (DEX)（一种强效皮质类固醇）的粘性水凝胶已被建议用于 AD 治疗。粘合复合水凝胶包含聚丙烯酰胺 (PAM) 和聚多巴胺 (PDA) 的双网络，嵌入超大孔介孔二氧化硅纳米粒子 (XL-MSN)。XL-MSN 的掺入进一步增强了多巴胺衍生的 PAM/PDA 水凝胶的固有皮肤粘附性，有助于同时增强水凝胶的内聚力和粘附力。所得粘性水凝胶具有高含水量和对猪皮的强粘附性。当 DEX 加载到 PAM/PDA 水凝胶中的 XL-MSN 的孔内时，与水凝胶中直接加载 DEX 的快速释放相比，DEX 会持续释放。载有 DEX 的 MSN@PAM/PDA 水凝胶在 AD 小鼠模型上的应用导致 AD 症状的显着抑制，包括增厚表皮层的恢复、皮肤中炎症细胞浸润的减少、胶原蛋白沉积的恢复和减少XL-MSN 嵌入的粘性水凝胶可能是局部给药治疗炎症性皮肤病的潜在平台。当 DEX 加载到 PAM/PDA 水凝胶中的 XL-MSN 的孔内时，与水凝胶中直接加载 DEX 的快速释放相比，DEX 会持续释放。载有 DEX 的 MSN@PAM/PDA 水凝胶在 AD 小鼠模型上的应用导致 AD 症状的显着抑制，包括增厚表皮层的恢复、皮肤中炎症细胞浸润的减少、胶原蛋白沉积的恢复和减少XL-MSN 嵌入的粘性水凝胶可能是局部给药治疗炎症性皮肤病的潜在平台。当 DEX 加载到 PAM/PDA 水凝胶中的 XL-MSN 的孔内时，与水凝胶中直接加载 DEX 的快速释放相比，DEX 会持续释放。载有 DEX 的 MSN@PAM/PDA 水凝胶在 AD 小鼠模型上的应用导致 AD 症状的显着抑制，包括增厚表皮层的恢复、皮肤中炎症细胞浸润的减少、胶原蛋白沉积的恢复和减少XL-MSN 嵌入的粘性水凝胶可能是局部给药治疗炎症性皮肤病的潜在平台。