Benzo-Fused-Ring Toolbox Based on Palladium/Norbornene Cooperative Catalysis: Methodology Development and Applications in Natural Product Synthesis,Accounts of Chemical Research

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Benzo-Fused-Ring Toolbox Based on Palladium/Norbornene Cooperative Catalysis: Methodology Development and Applications in Natural Product Synthesis
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2023-01-30 , DOI: 10.1021/acs.accounts.2c00781
Hong-Gang Cheng ₁ , Shihu Jia ₁ , Qianghui Zhou ₂

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Benzo-fused skeletons are ubiquitous in agrochemicals, medicines, natural products, catalysts, and other organic function materials. The assembly of these skeletons in an efficient manner is an actively explored field in organic synthesis. Palladium/norbornene (Pd/NBE) cooperative catalysis is a powerful tool for the expeditious assembly of polysubstituted arenes through bis-functionalization of the ortho and ipso positions of aryl iodides in one operation. Owing to the efforts of Lautens, Catellani, and others, an array of Pd/NBE-promoted annulations for the syntheses of diversified benzo-fused rings have been developed. However, these methods have not been broadly applied in total synthesis yet.

中文翻译：

基于钯/降冰片烯协同催化的苯并稠环工具箱：方法学开发及其在天然产物合成中的应用

苯并稠合骨架普遍存在于农用化学品、药物、天然产物、催化剂和其他有机功能材料中。以有效的方式组装这些骨架是有机合成中一个积极探索的领域。钯/降冰片烯 (Pd/NBE) 协同催化是通过一次操作中芳基碘化物的邻位和 ipso 位置的双官能化来快速组装多取代芳烃的有力工具。由于 Lautens、Catellani 和其他人的努力，已经开发出一系列用于合成多样化苯并稠合环的 Pd/NBE 促进环化反应。然而，这些方法尚未广泛应用于全合成。

更新日期：2023-01-30

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