Acute myeloid leukemia (AML) is a heterogeneous malignant condition characterized by massive infiltration of poorly differentiated white blood cells in the blood stream, bone marrow, and extramedullary sites. During leukemic development, hepatosplenomegaly is expected to occur because large blood volumes are continuously filtered through these organs. We asked whether infiltration of leukemic blasts initiated a response that could be detected in the interstitial fluid phase of the spleen and liver.

中文翻译：

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淋巴分离显示大鼠模型白血病发展过程中脾脏和肝脏中 STAT3 和 CREB ​​通路失调

急性髓性白血病 (AML) 是一种异质性恶性疾病，其特征是低分化白细胞大量浸润在血流、骨髓和髓外部位。在白血病发展过程中，预计会发生肝脾肿大，因为大量血液不断通过这些器官过滤。我们询问白血病母细胞的浸润是否引发了一种可以在脾脏和肝脏的间质液相中检测到的反应。