Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes,Liver Cancer

当前位置： X-MOL 学术 › Liver Cancer › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes
Liver Cancer ( IF 13.8 ) Pub Date : 2023-01-24 , DOI: 10.1159/000527498
Wen-Jia Cai ₁ , Minghua Ying ₂ , Rong-Qin Zheng ₃ , Jintang Liao ₄ , Baoming Luo ₅ , Lina Tang ₆ , Wen Cheng ₇ , Hong Yang ₈ , An Wei ₉ , Yilin Yang ₁₀ , Hui Wang ₁₁ , Yan-Chun Luo ₁ , Cun Liu ₁₂ , Hui Zhong ₁₃ , Qi Yang ₁₄ , Jie Yu ₁ , Ping Liang ₁

Affiliation

Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China.
Department of Diagnostic Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Department of Medical Ultrasound, Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Department of Diagnostic Ultrasound, Xiangya Hospital Central South University, Changsha, China.
Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Diagnostic Ultrasound, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, China.
Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Interventional Ultrasound, Hunan Provincial People's Hospital, Changsha, China.
Department of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Ultrasound, Jinan Central, Hospital Affiliated to Shandong First Medical University, Jinan, China.
Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Department of Medical Ultrasound, Peking University Shenzhen Hospital, Shenzhen, China.

Introduction: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection. Methods: Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67 and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI- RADS categories were further analyzed. Results: A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p < 0.001) and levels of Ki-67 (p = 0.01), and that poor differentiation (32.7% in LR-M, 12% in LR-5 and 6.2% in LR-4) (p < 0.001) and high level of Ki-67 (median value 30%) were more frequently classified into the LR-M category, whereas well differentiation (37.5% in LR-4, 15.1% in LR-5 and 11.5% in LR-M) and low levels of Ki-67 (median value 11%) were more frequently classified into the LR-4 category. No significant differences were found between MVI and CEUS LI-RADS categories (p > 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection. Conclusions: Biological characteristics of HCC, including differentiation and level of Ki-67 expression could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection.

更新日期：2023-01-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文

全部期刊列表>>