The current study was aimed to enhance the solubility, dispersibility and biotransformation efficacy of ellagic acid (EA) by preparing food-derived ellagic acid-Undaria pinnatifida polysaccharides solid dispersion (EA/UPP SD). The results demonstrated that the solubility of EA/UPP SD was improved from 0.014 mg/mL to 0.383 mg/mL, and the enhancement was related to converting to a more amorphous state and restraining its self-aggregation during the mechanochemical process. The structure of EA/UPP SDs was mostly maintained by hydrogen bonds and hydrophobic interactions between EA and UPP. Moreover, the result of in vitro anaerobic incubations showed the biotransformation process was improved with EA/UPP SD addition to substrate due to the advance of microbial accessibility in EA dispersion. Altogether, these results indicated that the EA/UPP SDs expanded the application of EA by increasing the solubility and dispersity, and provided a theoretical basis for bioconversion efficiency enhancement.

本研究旨在通过制备食品源性鞣花酸-裙带菜多糖固体分散体（EA/UPP SD）来提高鞣花酸（EA）的溶解度、分散性和生物转化功效。结果表明，EA/UPP SD 的溶解度从 0.014 mg/mL 提高到 0.383 mg/mL，这种提高与在机械化学过程中转化为更加无定形状态并抑制其自聚集有关。 EA/UPP SDs 的结构主要通过 EA 和 UPP 之间的氢键和疏水相互作用来维持。此外，体外厌氧培养的结果表明，由于 EA 分散体中微生物可及性的提高，在底物中添加 EA/UPP SD 可以改善生物转化过程。总之，这些结果表明EA/UPP SDs通过增加溶解度和分散性扩展了EA的应用，并为提高生物转化效率提供了理论基础。