In order to improve the solubility and the long-cycle performance of hydrophobic drug sorafenib (SOR), and to obtain an ideal smart drug delivery system for the effective treatment of liver cancer, S-SMIP, a pH/GSH double-sensitive sorafenib stealth imprinting material, was successfully prepared by UV-initiated surface imprinted polymerization on the basis of polyethylene glycol 2000 (PEG₂₀₀₀) acted as “gate keeper” modified magnetic substrate. The results showed that S-SMIP had a good adsorption capacity of 260.0 mg g⁻¹ and an excellent selectivity factor α 2.33. S-SMIP's kinetic adsorption data accorded well with the pseudo-second-order model and its mechanism was controlled mainly by chemical adsorption. The drug release experiments in vitro indicated S-SMIP could not only greatly improve the solubility of SOR, but also had the pH/GSH dual-sensitive response performance. Compared with the non-stealth imprinted material SMIP, S-SMIP still had a better long-cycle effect on the release of SOR, increasing to160 h from 130 h. So, the target material S-SMIP could greatly prolong the half-life of SOR, which provided a good idea for the development of a smart drug delivery system.

中文翻译：

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基于聚乙二醇改性磁印迹材料的新型智能隐形索拉非尼给药系统

为提高疏水性药物索拉非尼（SOR）的溶解性和长周期性能，获得理想的智能给药系统以有效治疗肝癌，S-SMIP，一种pH/GSH双敏索拉非尼隐形以聚乙二醇2000（PEG ₂₀₀₀）为“守门人”改性磁性基材，通过紫外引发表面印迹聚合成功制备了印迹材料。结果表明，S-SMIP 具有良好的吸附容量，为 260.0 mg g ^-1以及出色的选择性因子 α 2.33。S-SMIP的动力学吸附数据符合准二级模型，其机理主要受化学吸附控制。体外药物释放实验表明，S-SMIP不仅可以大大提高SOR的溶解度，而且具有pH/GSH双重敏感响应性能。与非隐形印迹材料SMIP相比，S-SMIP对SOR释放的长周期效应仍然较好，从130 h增加到160 h。因此，目标材料S-SMIP可以大大延长SOR的半衰期，为智能给药系统的开发提供了良好的思路。