Photoreductive β-aminoalkylation with amino acids affords functionalized γ-aminoketones for nucleoside mimics,Chemical Communications

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Photoreductive β-aminoalkylation with amino acids affords functionalized γ-aminoketones for nucleoside mimics
Chemical Communications ( IF 4.3 ) Pub Date : 2023-01-23 , DOI: 10.1039/d2cc06071j
Sebastian O Klein _{1,

2} , Adina A Baniahmad ₁ , Manfred Jung _{1,

2}

Affiliation

We developed a facile photoreductive and stereoselective β-aminoalkylation of a crowded enone by blue LED light irradiation using a wide variety of α-amino acids in order to access 5′-amino substituted carbasugar nucleosides for SAM-based methyltransferase inhibitors. This photochemical method provides highly functionalized carbasugar mimics for nucleoside analogue synthesis.

中文翻译：

用氨基酸进行光还原 β-氨基烷基化，为核苷模拟物提供功能化的 γ-氨基酮

我们开发了一种通过蓝色 LED 光照射使用多种 α-氨基酸对拥挤的烯酮进行简便的光还原和立体选择性 β-氨基烷基化，以便获得用于基于 SAM 的甲基转移酶抑制剂的 5'-氨基取代的卡巴糖核苷。这种光化学方法为核苷类似物的合成提供了高度功能化的卡巴糖模拟物。

更新日期：2023-01-26

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