Visible light responsive photoacids for subcellular pH and temperature correlated fluorescence sensing,Chemical Communications

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Visible light responsive photoacids for subcellular pH and temperature correlated fluorescence sensing
Chemical Communications ( IF 4.3 ) Pub Date : 2023-01-21 , DOI: 10.1039/d2cc06816h
Yu Cheng _{1,

2} , Xueqing Ma _{1,

2} , Jingying Zhai _{3,

4} , Xiaojiang Xie _{1,

2,

4}

Affiliation

Liao's photoacids (PAs) are a well-known type of visible light-responsive photoswitches. Here, taking advantage of the temperature-dependent thermal relaxation from the ring-closed to the ring-opened forms, PAs are proposed for the first time as a fluorescent temperature sensor in cells. The logarithmic lifetime (ln τ) of the ring-closed spiro-form exhibited an excellent linear response to the reciprocal of the temperature. In addition, the fluorescent ring-opened PAs were able to highlight lysosomes and responded to lysosomal pH changes. These properties made the PAs promising fluorescent probes in the sensing of subcellular pH and temperature.

中文翻译：

用于亚细胞 pH 和温度相关荧光传感的可见光响应光酸

Liao 的光酸 (PA) 是一种众所周知的可见光响应光开关。在这里，利用从闭环到开环形式的温度依赖性热弛豫，PA 首次被提议作为细胞中的荧光温度传感器。闭环螺旋形的对数寿命 (ln τ ) 对温度的倒数表现出极好的线性响应。此外，荧光开环 PA 能够突出溶酶体并对溶酶体 pH 值变化做出反应。这些特性使 PA 在检测亚细胞 pH 和温度方面很有前途。

更新日期：2023-01-25

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