Chronic hyperglycemia increases pancreatic β-cell metabolic activity, contributing to glucotoxicity-induced β-cell failure and loss of functional β-cell mass, potentially in multiple forms of diabetes. In this perspective we discuss the novel paradoxical and counterintuitive concept of inhibiting glycolysis, particularly by targeted inhibition of glucokinase, the first enzyme in glycolysis, as an approach to maintaining glucose sensing and preserving functional β-cell mass, thereby improving insulin secretion, in the treatment of diabetes.

中文翻译：

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葡萄糖激酶抑制：糖尿病的新疗法？


慢性高血糖会增加胰腺 β 细胞代谢活性，导致糖毒性诱导的 β 细胞衰竭和功能性 β 细胞质量丧失，可能导致多种形式的糖尿病。从这个角度来看，我们讨论了抑制糖酵解的新的矛盾和违反直觉的概念，特别是通过靶向抑制葡萄糖激酶（糖酵解中的第一种酶）作为维持葡萄糖感应和保留功能性 β 细胞质量的方法，从而改善胰岛素分泌，在治疗糖尿病。