Oncogenic role for an EWS–FLI1 suppressor,Nature Cell Biology

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Oncogenic role for an EWS–FLI1 suppressor
Nature Cell Biology ( IF 17.3 ) Pub Date : 2023-01-19 , DOI: 10.1038/s41556-022-01067-8
April A Apfelbaum ₁ , Elizabeth R Lawlor ₁

Affiliation

Tight regulation of the activity of EWS–ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis.

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