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A phototoxic thulium complex exhibiting intracellular ROS production upon 630 nm excitation in cancer cells
Chemical Communications ( IF 4.3 ) Pub Date : 2023-01-19 , DOI: 10.1039/d2cc06209g
Daniel Obitz 1 , Karmel S Gkika 2 , Marvin Heller 1 , Tia E Keyes 2 , Nils Metzler-Nolte 1
Affiliation  

A lanthanide(III) complex with a thulium metal centre connected via a terpyridine unit to a light harvesting antenna with strong absorption in the therapeutic window [>590 nm] was synthesised and tested as a possible photosensitiser (PS) in photodynamic therapy (PDT). The complex exhibited significant phototoxic activity on cancer cells upon irradiation in the therapeutic window and from intracellular and solution studies ROS production was identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold lowered IC50 value was obtained upon irradiation compared to the dark control.

中文翻译:

一种光毒性铥复合物,在 630 nm 激发下在癌细胞中表现出细胞内 ROS 的产生

合成了具有铥金属中心的镧系元素 ( III ) 络合物,该络合物通过三联吡啶单元连接到在治疗窗口 [>590 nm] 中具有强吸收的光收集天线,并作为光动力疗法 (PDT) 中可能的光敏剂 (PS) 进行了测试. 该复合物在治疗窗口照射后对癌细胞表现出显着的光毒性活性,并且根据细胞内和溶液研究,ROS 的产生被确定为该化合物的光毒性作用方式。在细胞活力测定中,与暗对照相比,照射后获得降低 10 倍的 IC 50值。
更新日期:2023-01-19
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