Manganese(II)-Guided Separation in the Sub-Nanometer Regime for Precise Identification of In Vivo Size Dependence,Angewandte Chemie International Edition

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Manganese(II)-Guided Separation in the Sub-Nanometer Regime for Precise Identification of In Vivo Size Dependence
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-01-18 , DOI: 10.1002/anie.202214720
Wei Cai ₁ , Yue Tan ₁ , Kui He ₁ , Bing Tang ₁ , Jinbin Liu ₁

Affiliation

We report a facile one-step in situ Mn²⁺-guided centrifugation strategy to synthesize large-scale ultrasmall AuNPs with the size gradient decrease precisely controlled at the sub-nanometer regime, and further demonstrate that the sub-nanometer size differences (approximately 0.5 nm) significantly alter the non-specific phagocytosis of AuNPs in macrophages of the reticuloendothelial system, elimination rate, and nanotoxicology.

中文翻译：

亚纳米范围内的锰 (II) 引导分离，用于精确识别体内尺寸依赖性

我们报告了一种简单的一步原位 Mn ²⁺引导离心策略合成大规模超小 AuNPs，其尺寸梯度减小精确控制在亚纳米范围内，并进一步证明亚纳米尺寸差异（约 0.5 nm) 显着改变 AuNPs 在网状内皮系统巨噬细胞中的非特异性吞噬作用、消除率和纳米毒理学。

更新日期：2023-01-18

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