Diversified access to di- and trisubstituted allenes via nickel-catalysed reactions of 1,3-enynes with alkyl N-hydroxyphthalimide esters,Chemical Communications

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Diversified access to di- and trisubstituted allenes via nickel-catalysed reactions of 1,3-enynes with alkyl N-hydroxyphthalimide esters
Chemical Communications ( IF 4.3 ) Pub Date : 2023-01-18 , DOI: 10.1039/d2cc06544d
Hong Liu ₁ , Wan Lei ₁ , Yan Li ₁ , Yewen Fang _{2,

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Affiliation

Herein, a new nickel-catalysed protocol for the preparation of di- and trisubstituted allenes has been successfully developed via the reactions of 1,3-enynes with alkyl N-hydroxyphthalimide esters. The new method based on a reductive radical-polar crossover (RPC) process features broad substrate scope, wide functional group tolerance, and a simple catalyst system. The late-stage allenylation of drugs has also been illustrated.

中文翻译：

通过 1,3-烯炔与烷基 N-羟基邻苯二甲酰亚胺酯的镍催化反应，获得二和三取代的丙二烯的多样化途径

在此，通过1,3-烯炔与烷基N-羟基邻苯二甲酰亚胺酯的反应，成功开发了一种用于制备二取代和三取代丙二烯的新型镍催化方案。基于还原性自由基-极性交叉 (RPC) 工艺的新方法具有广泛的底物范围、广泛的官能团耐受性和简单的催化剂体系。还说明了药物的后期烯丙基化。

更新日期：2023-01-18

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