A “dual-key-and-lock” ratiometric fluorescent probe with biocompatibility and selectivity for imaging vicinal dithiol proteins,Chemical Communications

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A “dual-key-and-lock” ratiometric fluorescent probe with biocompatibility and selectivity for imaging vicinal dithiol proteins
Chemical Communications ( IF 4.3 ) Pub Date : 2023-01-18 , DOI: 10.1039/d2cc06422g
Guang-Yue Zou ₁ , Yun Wen ₁ , Fan Bi ₁ , Shuai Chen ₁ , Yong-Liang Yu ₁ , Jian-Hua Wang ₁

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TMR-TPE, a ratiometric fluorescent probe, was reported for the imaging of vicinal dithiol proteins (VDPs) in living cells. Profiting from the “dual-key-and-lock” design, TMR-TPE solves the toxicity problem of VDP probes (98% cell viability at 50 μM) and avoids the interference of small thiols (up to 10 mM GSH). The change of VDPs during drug-induced liver injury was monitored for the first time using TMR-TPE.

中文翻译：

一种具有生物相容性和选择性的“双钥匙锁”比例荧光探针，用于成像邻位二硫醇蛋白

TMR-TPE 是一种比例荧光探针，据报道可用于活细胞中邻位二硫醇蛋白 (VDP) 的成像。得益于“双钥匙锁”设计，TMR-TPE 解决了 VDP 探针的毒性问题（50 μM 时 98% 的细胞活力）并避免了小硫醇（高达 10 mM GSH）的干扰。首次使用 TMR-TPE 监测药物性肝损伤期间 VDPs 的变化。

更新日期：2023-01-18

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