The receptor tyrosine kinase DDR1 is mechanoresponsive to extracellular matrix (ECM) stiffness and affects Hippo and YAP signalling, but the precise mechanisms of this are unclear. Liu et al. report that DDR1 regulates YAP and that ECM stiffness can stimulate liquid–liquid phase separation of both DDR1 and the Hippo pathway kinase LATS1.

中文翻译：

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液体 DDR1 响应刚度

受体酪氨酸激酶 DDR1 对细胞外基质 (ECM) 刚度有机械反应并影响 Hippo 和 YAP 信号，但其确切机制尚不清楚。刘等人。报告 DDR1 调节 YAP，ECM 刚度可以刺激 DDR1 和 Hippo 通路激酶 LATS1 的液-液相分离。