Signal transduction from the plasma membrane involves local recruitment and activation of proteins, which can occur via the lipid PI(4,5)P2 (phosphatidyl-D-myo-inositol-4,5-bisphosphate). Whether its binding partners indirectly enrich the lipid at plasma membrane subdomains or pools of the lipids are first created locally has been unclear. Pacheco et al. have now determined the trajectories of PI(4,5)P2 at the plasma membrane and how they may be affected by PI(4,5)P2-binding complexes.

中文翻译：

---

质膜脂质扩散

来自质膜的信号转导涉及蛋白质的局部募集和激活，这可以通过脂质 PI(4,5)P2（磷脂酰-D-肌醇-4,5-二磷酸）发生。它的结合伙伴是间接富集质膜亚域的脂质还是首先在局部产生脂质库尚不清楚。帕切科等。现在已经确定了 PI(4,5)P2 在质膜上的轨迹以及它们如何受到 PI(4,5)P2 结合复合物的影响。