The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively affected by the formation of tumor cell resistant clone and the severe toxicity of chemotherapy drugs to normal tissues. In accordance with research findings, in the comprehensive targeted therapy of TNBC, the nano delivery system effectively suppresses and kills tumor cells on the basis of its unique targeting properties as well as the ability to co-load, deliver, and release chemotherapeutic drugs, active gene fragments and immune enhancing factors, etc. When combined with photothermal ablation therapy, the synergism and toxicity reduction effect of chemotherapy drugs, the inhibition of tumor proliferation related genes as well as activation of immune system can be achieved. Nanoparticle delivery systems present a totally new way of drug design and usage, and change the pharmacokinetic characteristics of conventional chemotherapeutic drugs with significantly reduced adverse effects of some otherwise very toxic chemodrugs via targeted delivery. In this paper, a detailed review was carried out focusing on the research progress of nanoparticle delivery system in the comprehensive targeted therapy of TNBC. We also summarize the merits, shortcomings, perspectives and future developments of nanoparticle-drug delivery systems.

高度恶性三阴性乳腺癌（TNBC）的治疗效果受到肿瘤细胞耐药克隆的形成和化疗药物对正常组织的严重毒性的负面影响。根据研究结果，在TNBC的综合靶向治疗中，纳米递送系统凭借其独特的靶向特性以及共载、递送和释放化疗药物的能力，有效地抑制和杀伤肿瘤细胞，活性基因片段和免疫增强因子等。与光热消融治疗相结合，可以达到化疗药物的协同减毒作用，抑制肿瘤增殖相关基因，激活免疫系统。纳米颗粒递送系统提供了一种全新的药物设计和使用方式，并通过靶向递送改变了传统化学治疗药物的药代动力学特征，显着降低了一些毒性很强的化学药物的副作用。本文重点对纳米颗粒递送系统在TNBC综合靶向治疗中的研究进展进行了详细综述。我们还总结了纳米颗粒药物递送系统的优点、缺点、前景和未来发展。重点对纳米颗粒给药系统在TNBC综合靶向治疗中的研究进展进行了详细综述。我们还总结了纳米颗粒药物递送系统的优点、缺点、前景和未来发展。重点对纳米颗粒给药系统在TNBC综合靶向治疗中的研究进展进行了详细综述。我们还总结了纳米颗粒药物递送系统的优点、缺点、前景和未来发展。