Nitrene transfer reaction with hydroxylamine derivatives,Chemical Communications

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Nitrene transfer reaction with hydroxylamine derivatives
Chemical Communications ( IF 4.3 ) Pub Date : 2023-01-16 , DOI: 10.1039/d2cc06318b
Yang Gao _{1,

2} , Haixia Li ₁ , Yupeng Zhao ₁ , Xiao-Qiang Hu ₃

Affiliation

Recent progress on catalytic nitrene transfer reactions with hydroxylamine derivatives as prevalent precursors is summarized in this highlight. The salient features of these N–O derived nitrene transfer reagents are that they are readily available, bench-stable, and can be facilely activated by a range of transition metal-catalysts under mild conditions. The application of these reagents in transition metal-catalysis has led to many new amidation or amination reactions, such as C–H insertions and aziridination of olefins. These reagents have also been applied in difunctionalisation of unsaturated bonds, dearomative amination of indoles, and formation of N–X bonds. Moreover, the recent achievements in photocatalysis and enzyme catalysis further emphasize the importance of these appealing reagents. This highlight provides an overview of these reactions reported in recent years. Challenges and potential opportunities for future developments are also discussed.

中文翻译：

与羟胺衍生物的氮烯转移反应

本期重点总结了以羟胺衍生物作为普遍前体的催化氮烯转移反应的最新进展。这些 N-O 衍生的氮烯转移试剂的显着特征是它们易于获得、实验室稳定，并且可以在温和条件下被一系列过渡金属催化剂轻松激活。这些试剂在过渡金属催化中的应用导致了许多新的酰胺化或胺化反应，例如 C-H 插入和烯烃的氮丙啶化。这些试剂也已应用于不饱和键的双官能化、吲哚的去芳香胺化和 N-X 键的形成。此外，最近在光催化和酶催化方面的成就进一步强调了这些有吸引力的试剂的重要性。本重点概述了近年来报道的这些反应。还讨论了未来发展的挑战和潜在机遇。

更新日期：2023-01-21

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