In burns, reactive oxygen species (ROS) imbalance can lead to elevated oxidative damage and increase the difficulty of skin repair. However, rough removal of ROS will inevitably affect its' normal physiological function, leading to antibacterial failure and slow wound healing. To solve this problem, we developed a multifunctional AC-AuLA supramolecular polymer by combining medication therapy of asiaticoside (AC), photothermal therapy (PTT) of gold nanostars (AuNSs), and ROS-mediated of α-lipoic acid (LA). The AC-AuLA could create a normal ROS microenvironment for burns by regulating the balance between oxidants and antioxidants. At the same time, the AuNSs endow AC-AuLA with an excellent antibacterial effect, and the AC of AC-AuLA can promote wound repair through robust cell proliferation and angiogenesis. Importantly, in burn models infected with S. aureus, AC-AuLA achieves dense vascular formation and uniform collagen alignment, accelerating wound closure. These results indicate that this novel redox-sensitive supramolecular polymer has a broad application prospect in burn wound repair platforms.

在烧伤中，活性氧 (ROS) 失衡会导致氧化损伤升高，增加皮肤修复的难度。然而，粗暴地去除ROS势必会影响其正常的生理功能，导致抗菌失效和伤口愈合缓慢。为了解决这个问题，我们通过结合积雪草苷 (AC) 的药物疗法、金纳米星 (AuNSs) 的光热疗法 (PTT) 和活性氧介导的 α-硫辛酸 (LA)，开发了一种多功能 AC-AuLA 超分子聚合物。AC-AuLA 可以通过调节氧化剂和抗氧化剂之间的平衡，为烧伤创造一个正常的 ROS 微环境。同时，AuNSs 赋予 AC-AuLA 优异的抗菌作用，AC-AuLA 的 AC 可通过强大的细胞增殖和血管生成促进伤口修复。重要的，金黄色葡萄球菌，AC-AuLA 实现致密的血管形成和均匀的胶原排列，加速伤口闭合。这些结果表明这种新型氧化还原敏感的超分子聚合物在烧伤创面修复平台中具有广阔的应用前景。