Abstract The lack of sufficient mechanical stimulation to the human bone, results in disuse osteoporosis. Low-intensity pulsed ultrasound (LIPUS) promotes fracture healing and the treatment of disuse osteoporosis, but its biomechanical mechanism remains unknown. Simulative research on the mechanical effects of LIPUS on disuse trabecular bone and osteoblasts have been performed. The von Mises stress of disuse trabecular bone and osteoblasts obviously increased under LIPUS irradiation. The average von Mises stress of osteoblasts were two orders of magnitude higher under the irradiation of simulant LIPUS than that without LIPUS irradiation, and the von Mises stress of osteoblasts was positively correlated with the amplitude of sound pressure excitation. The results showed that LIPUS irradiation could obviously improve the mechanical micro-environment of trabecular bone and osteoblasts to alleviate the lack of mechanical stimulation. The results of the research can reveal the biomechanical mechanism of LIPUS in the treatment of disuse osteoporosis to some extent and provide theoretical guidance for clinical treatment of disuse osteoporosis through physical methods.

中文翻译：

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低强度脉冲超声对骨小梁和成骨细胞机械效应的数值研究

摘要人体骨骼缺乏足够的机械刺激，会导致废用性骨质疏松症。低强度脉冲超声（LIPUS）可促进骨折愈合和废用性骨质疏松症的治疗，但其生物力学机制仍不清楚。对LIPUS对废用骨小梁和成骨细胞的机械效应进行了模拟研究。 LIPUS照射下废用骨小梁和成骨细胞的von Mises应力明显增加。模拟LIPUS照射下成骨细胞的平均von Mises应力比未照射LIPUS时高2个数量级，且成骨细胞von Mises应力与声压激发幅度呈正相关。结果表明，LIPUS照射可以明显改善骨小梁和成骨细胞的机械微环境，缓解机械刺激的缺乏。研究结果可在一定程度上揭示LIPUS治疗废用性骨质疏松症的生物力学机制，为临床通过物理方法治疗废用性骨质疏松症提供理论指导。