Alkenes are versatile compounds that are readily available on a large scale from industry or through organic synthesis. The widespread occurrence of alkenes provides the continuous impetus for the development of catalytic asymmetric alkene hydrofunctionalizations, which enables expeditious construction of complex chiral molecules from readily available starting materials. Catalytic asymmetric hydrofunctionalization of internal alkenes presents a notable challenge, due to their low reactivity, many potential side reactions, and the simultaneous control of the regio-, diastereo-, and enantioselectivities.

中文翻译：

---

配位辅助：金属催化的内部烯烃区域和对映选择性氢炔基化的强大策略

烯烃是多种多样的化合物，很容易从工业或有机合成中大规模获得。烯烃的广泛存在为催化不对称烯烃加氢官能化的发展提供了持续的动力，这使得能够从容易获得的起始材料快速构建复杂的手性分子。由于内部烯烃的低反应性、许多潜在的副反应以及区域选择性、非对映选择性和对映选择性的同时控制，内烯烃的催化不对称加氢官能化是一个显着的挑战。