Structural and functional map for forelimb movement phases between cortex and medulla,Cell

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Structural and functional map for forelimb movement phases between cortex and medulla
Cell ( IF 45.5 ) Pub Date : 2023-01-05 , DOI: 10.1016/j.cell.2022.12.009
Wuzhou Yang ₁ , Harsh Kanodia ₁ , Silvia Arber ₁

Affiliation

The cortex influences movement by widespread top-down projections to many nervous system regions. Skilled forelimb movements require brainstem circuitry in the medulla; however, the logic of cortical interactions with these neurons remains unexplored. Here, we reveal a fine-grained anatomical and functional map between anterior cortex (AC) and medulla in mice. Distinct cortical regions generate three-dimensional synaptic columns tiling the lateral medulla, topographically matching the dorso-ventral positions of postsynaptic neurons tuned to distinct forelimb action phases. Although medial AC (MAC) terminates ventrally and connects to forelimb-reaching-tuned neurons and its silencing impairs reaching, lateral AC (LAC) influences dorsally positioned neurons tuned to food handling, and its silencing impairs handling. Cortico-medullary neurons also extend collaterals to other subcortical structures through a segregated channel interaction logic. Our findings reveal a precise alignment between cortical location, its function, and specific forelimb-action-tuned medulla neurons, thereby clarifying interaction principles between these two key structures and beyond.

中文翻译：

皮质和髓质之间前肢运动阶段的结构和功能图

皮层通过对许多神经系统区域进行广泛的自上而下的投射来影响运动。熟练的前肢运动需要延髓中的脑干回路；然而，皮质与这些神经元相互作用的逻辑仍未被探索。在这里，我们揭示了小鼠前皮质（AC）和髓质之间的细粒度解剖和功能图。不同的皮质区域产生三维突触柱，平铺于外侧髓质，在地形上匹配突触后神经元的背腹位置，调整到不同的前肢动作阶段。虽然内侧 AC (MAC) 终止于腹侧，并连接到前肢伸手调节的神经元，并且其沉默会损害伸手，但外侧 AC (LAC) 会影响调节到食物处理的背侧神经元，并且其沉默会损害处理。皮质髓质神经元还通过隔离通道相互作用逻辑将侧枝延伸到其他皮质下结构。我们的研究结果揭示了皮质位置、其功能和特定前肢动作调节的髓质神经元之间的精确对准，从而阐明了这两个关键结构之间及其他结构之间的相互作用原理。

更新日期：2023-01-05

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