ABSTRACT

To present the efficacy of autologous neurosensory retinal transplantation in macular holes surgery with rhegmatogenous retinal detachment. Eleven eyes of 11 patients with rhegmatogenous retinal detachment associated to a large macular hole were enrolled between January 2019 and January 2021 in the Department A of the Hedi Rais Institute of Ophthalmology (Tunis, Tunisia). All patients underwent a 23 G pars plana vitrectomy. An autologous neurosensory retinal patch was placed inside the macular hole. Long-acting silicone tamponade was carried out. Clinical features of the macular area, best-corrected visual acuity (BCVA), fundus examination, and SD-OCT were recorded before surgery, at 1- and 3-month follow-up after surgery. The mean age of our population was 56.6 ± 10.33 years old, ranged from 45 to 76 years old. Final retinal reattachment was achieved clinically in all eyes. The Spectral domain-Optical Coherence Tomography (SD-OCT) follow-up showed the macular hole closure. The retinal patch was demonstrated by OCT at each control. BCVA improved from 1.52 ± 0.23 Logarithm of the Minimum Angle of Resolution (LogMAR) to 0.89 ± 0.16 LogMAR 3 months after surgery (p= 0.014). No adverse events were registered during the study. Autologous neurosensory retinal transplantation has been efficient to treat macular hole associated to rhegmatogenous retinal detachment. Further multicentric studies with a large number of patients are needed to establish the results of this technique in complex cases.

摘要

介绍自体神经感觉视网膜移植在伴有孔源性视网膜脱离的黄斑裂孔手术中的疗效。2019 年 1 月至 2021 年 1 月期间，Hedi Rais 眼科研究所（突尼斯，突尼斯）的 A 科招募了 11 名与大黄斑裂孔相关的孔源性视网膜脱离患者的 11 只眼睛。所有患者均接受了 23 G 睫状体玻璃体切除术。自体神经感觉视网膜贴片被放置在黄斑裂孔内。进行了长效硅胶填塞。术前、术后 1 个月和 3 个月随访时记录黄斑区的临床特征、最佳矫正视力 (BCVA)、眼底检查和 SD-OCT。我们人口的平均年龄为 56.6 ± 10.33 岁，介于 45 至 76 岁之间。所有眼睛在临床上都实现了最终的视网膜复位。光谱域光学相干断层扫描 (SD-OCT) 随访显示黄斑裂孔闭合。视网膜斑块由 OCT 在每个对照中展示。术后 3 个月，BCVA 从最小分辨率对数 (LogMAR) 的 1.52 ± 0.23 提高到 0.89 ± 0.16 LogMAR (p = 0.014）。研究期间没有记录到不良事件。自体神经感觉视网膜移植已有效治疗与孔源性视网膜脱离相关的黄斑裂孔。需要对大量患者进行进一步的多中心研究，以确定该技术在复杂病例中的结果。